| AMG S 63 E PERFORMANCE V8 (802 Hp) Plug-in Hybrid 4MATIC+ AMG SPEEDSHIFT MCT 9G | Sedan | Petrol / electricity | M 177 | 4 | 2022 | |
| S 350d (286 Hp) 4MATIC 9G-TRONIC | Sedan | Diesel | OM 656.929 | 4 | 2020–2023 | |
| S 350d (286 Hp) 9G-TRONIC | Sedan | Diesel | OM 656.929 | 4 | 2020–2023 | |
| S 350d (313 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Diesel | OM 656.830 | 4 | 2023 | |
| S 350d (313 Hp) EQ Boost 9G-TRONIC | Sedan | Diesel | OM 656.830 | 4 | 2023 | |
| S 400d (330 Hp) 4MATIC 9G-TRONIC | Sedan | Diesel | OM 656.929 | 4 | 2020–2023 | |
| S 450 (367 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Petrol (Gasoline) | M 256.930 | 4 | 2020–2023 | |
| S 450 (381 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Petrol (Gasoline) | M 256.830 | 4 | 2023 | |
| S 450d (367 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Diesel | OM 656.830 | 4 | 2023 | |
| S 450e (408 Hp) Plug-in Hybrid 9G-TRONIC | Sedan | Petrol / electricity | M 256.930 | 4 | 2022 | |
| S 500 (435 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Petrol (Gasoline) | M 256.930 | 4 | 2020–2023 | |
| S 500 (449 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Petrol (Gasoline) | M 256.830 | 4 | 2023 | |
| S 580 V8 (503 Hp) EQ Boost 4MATIC 9G-TRONIC | Sedan | Petrol (Gasoline) | M 176.980 | 4 | 2021 | |
| S 580e (510 Hp) Plug-in Hybrid 4MATIC 9G-TRONIC | Sedan | Petrol / electricity | M 256.930 | 4 | 2021 | |
| S 580e (510 Hp) Plug-in Hybrid 9G-TRONIC | Sedan | Petrol / electricity | M 256.930 | 4 | 2021 | |